2020 - present:
Ojala KS. Ginebaugh SP. Wu M. Ortiz G. Miller EW. Ortiz G. Covarrubias M. Meriney SD. (2021) A high affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. Journal of Biological Chemistry. Jan 16:100302. doi: 10.1016/j.jbc.2021.100302.
Ojala KS. Reedich EJ. DiDonato CJ. Meriney SD. (2021) In Search of a Cure: The Development of Therapeutics to Alter the Progression of Spinal Muscular Atrophy. Brain Sciences. 11: 194. https://doi.org/10.3390/brainsci11020194
Ginebaugh SP. Cyphers ED. Lanka V. Ortiz G. Miller EW. Laghaei R. Meriney SD. (2020) The frog motor nerve terminal has very brief action potentials and three electrical regions predicted to differentially control transmitter release. Journal of Neuroscience. 40(18): 3504-3516.
Homan AE. Laghaei R. Dittrich M. Meriney SD. (2018) The impact of spatio-temporal calcium dynamics within presynaptic active zones on synaptic delay at the frog neuromuscular junction. J. Neurophysiol. 119: 688-699.
Meriney SD. Tarr TB. Ojala KS. Wu M. Li Y. Lacomis D. Garcia-Ocano A. Liang M. Valdomir G. Wipf P. (2018) Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Ann. N.Y. Acad. Sci. 1412: 73-81.
Wu M. White HV. Boehm B. Meriney CJ. Kerrigan K. Frasso M. Liang M. Gotway EM. Wilcox M. Johnson JW. Wipf P. Meriney SD. (2018) New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease. Neuropharmacology 131: 176-189.
Laghaei R. Ma J. Tarr TB. Homan AE. Kelly L. Tilvawala MS. Vuocolo BS. Rajasekaran HP. Meriney SD. Dittrich D. (2018) Transmitter release site organization can predict synaptic function at the neuromuscular junction. J. Neurophysiol. 119: 1340-1355.
Dittrich M. Homan AE. Meriney SD. (2018) Presynaptic mechanisms controlling calcium-triggered transmitter release at the neuromuscular junction. Current Opinion in Physiology 4: 15-24.
Homan AE. Meriney SD. (2018) Structure-function relationships between calcium channels and docked synaptic vesicles at neuromuscular transmitter release sites. Synapse 72 (11): 1-11. e22057.
Meriney SD. Lacomis D. (2018) Reported direct aminopyridine effects on voltage-gated calcium channels is a high-dose pharmacological off-target effect of no clinical relevance. J. Biol. Chem. 293: 16100.
Dittrich M. Meriney SD. (2016) Single calcium channels stand out in the crowd. Channels 10:1-2.
Tarr TB. Wipf P. Meriney SD. (2015) Synaptic pathophysiology and treatment of Lambert-Eaton myasthenic syndrome. Molecular Neurobiology 52(1): 456-63.
Luo F. Dittrich M. Cho S. Stiles JR. Meriney SD. (2015) Transmitter release is evoked with low probability predominately by calcium flux through single channel openings at the frog neuromuscular junction. Journal of Neurophysiology 113(7): 2480-9.
Ma J. Kelly L. Ingram J. Price TJ. Meriney SD. Dittrich M. (2015) New insights into short-term synaptic facilitation at the frog neuromuscular junction. Journal of Neurophysiology 113: 71-87.
Meriney SD. Umbach JA. Gundersen CB. (2014) Fast, Ca2+-dependent exocytosis at nerve terminals: shortcomings of SNARE-based models. Progress in Neurobiology 121: 55-90.
Tarr TB. Lacomis D. Reddel SW. Liang M. Valdomir G. Frasso M. Wipf P. Meriney SD. (2014) Complete reversal of neuromuscular disease-induced synapse impairment by a combination of 3,4-DAP and a novel calcium channel agonist. Journal of Physiology 592: 3687-3696.
Meriney SD. Dittrich M. (2013) Organization and function of transmitter release sites at the neuromuscular junction. Journal of Physiology 591: 3159-3165.
Dittrich M. Pattillo JM. King JD. Cho S. Stiles JR. Meriney SD. (2013) An excess calcium binding site model predicts neurotransmitter release at the NMJ. Biophysical Journal 104: 2751-2763.
Tarr TB. Malick W. Liang M. Valdomir G. Frasso M. Lacomis D. Reddel SW. Garcia-Ocano A. Wipf P. Meriney SD. (2013) Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton Myasthenic Syndrome. Journal of Neuroscience 33: 10559-10567.
Tarr TB. Dittrich M. Meriney SD. (2013) Are Unreliable Release Mechanisms Conserved from NMJ to CNS? (2012) Trends in Neuroscience 36: 14-22.
Tarr TB. Valdomir G. Liang M. Wipf P. Meriney SD. (2012) New calcium channel agonists as potential therapeutics in LEMS and other neuromuscular diseases. Annals of the New York Academy of Science 1275: 85-91.
Liang M. Tarr TB. Bravo-Altamirano K. Valdomir G. Rensch G. Swanson L. DeStefino NR. Mazzarisi CM. Olszewski RA. Wilson GM. Meriney SD. and Wipf P. (2012) Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist. ACS Medicinal Chemistry Letters 3: 985-990.
Burton SD. Johnson JW. Zeringue HC. Meriney SD. (2012) Distinct roles of neuroligin-1 and SynCAM1 in synapse formation and function in dissociated hippocampal neurons Neuroscience 215: 1-16.
Finegold DN. Baty CJ. Knickekbein KZ. Perschke S. Noon SE. Campbell D. Karlsson JM. Huang D. Kimak MA. Lawrence EC. Finegold E. Meriney SD. Brufsky AM. Feingold E. Ferrell RE. (2012) Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment. Clincal Cancer Research 18: 2382-2390.
Luo F. Dittrich M. Stiles JR. Meriney SD. (2011) Single pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals. Journal of Neuroscience 31: 11268-11281.
Cosgrove KE. Galvan EJ. Barrionuevo G. Meriney SD. (2011) mGluRs Modulate Strength and Timing of Excitatory Transmission in Hippocampal Area CA3. Molecular Neurobiology 44: 93-101.
Douthitt HL. Luo F. McCann SD. Meriney SD. (2011) Dynasore, an inhibitor of dynamin, increases the probability of transmitter release. Neuroscience 172: 187-195.
Cosgrove KE. Meriney SD. Barrionuevo G. (2011) High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons. Hippocampus 21: 1302-1317.
Ferrell RE. Baty CJ. Kimak MA. Karlsson JM. Lawrence EC. Franke-Snyder M. Meriney SD. Feingold E. Finegold DN. (2010) GJC2 Missense Mutations Cause Human Lymphedema, The American Journal of Human Genetics. 86: 943-948. doi:10.1016/j.ajhg.2010.04.010.
DeStefino NR. Pilato AA. Dittrich M. Cherry SV. Cho S. Joel R. Stiles JR. Meriney SD. (2010). (R)-Roscovitine prolongs the mean open time of unitary N-type calcium channel currents. Neuroscience 167: 838-849.
Cosgrove KE. Galvan EJ. Meriney SD. Barrionuevo G. (2010) Area CA3 interneurons receive two spatially segregated mossy fiber inputs. Hippocampus. 20: 1003-1009.
Galván EJ. Cosgrove KE. Mauna JC. Card JP. Thiels E. Meriney SD. Barrionuevo G. (2010) Critical involvement of postsynaptic protein kinase activation in LTP at hippocampal mossy fiber synapses on CA3 interneurons. Journal of Neuroscience 30: 2844-2855
Meunier FA. Nguyen TH. Colasante C. Luo F. Sullivan RKP. Lavidis NA. Molgo J. Meriney SD. Schiavo G. (2010) Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin. Journal of Cell Science 123: 1131-1140.
Keith RK. Poage RE. Yokoyama CT. Catterall WA. Meriney SD. (2007) Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo. Journal of Neuroscience 27: 265-269.
Cho S. Meriney SD. (2006) The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction. European Journal of Neuroscience 23: 3200-3208.
King JD. Meriney SD. (2005) Proportion of N-type calcium current activated by action potential stimuli. Journal of Neurophysiology 94: 3762-3770.
Wachman E. Poage RE. Stiles JR. Farkas D. Meriney SD. (2004) Spatial distribution of calcium entry evoked by single action potentials within the presynaptic active zone. Journal of Neuroscience 24: 2877-2885.
Choh V. Sivak JG. Meriney SD. (2002) A physiological model to measure effects of age on lenticular accommodation and spherical aberration in chickens. Investigative Ophthalmology & Visual Science 43: 92-98.
Poage, R.E. & S.D. Meriney (2002) Presynaptic calcium influx, neurotransmitter release and neuromuscular disease. Physiology and Behavior 77: 507-512.
Pattillo JM. Yazejian B. DiGregorio DA. Vergara JL. Grinnell AD. Meriney SD. (2001) Contribution of presynaptic calcium-activated potassium currents to transmitter release regulation in cultured Xenopus nerve-muscle synapses. Neuroscience 102: 229-240.
Artim DE. Meriney SD. (2000) G-protein-modulated Ca2+ current with slowed activation does not alter the kinetics of action potential-evoked Ca2+ current. Journal of Neurophysiology 84: 2417-2425.
Pattillo JM. Artim DE. Simples JE. Meriney SD. (1999) Variations in onset of action potential broadening: effects on calcium current studied in chick ciliary ganglion neurons. Journal of Physiology (London) 514: 719-728.
Gray DB. Polo-Parada L. Pilar GR. Eang P. Metzger RR. Klann E. Meriney SD. (1999) A nitric oxide/cGMP dependent protein kinase pathway interacts with somatostatin-mediated inhibition of transmitter release downstream of calcium entry. Journal of Neurochemistry 72: 1981-1990.
Poage RE. Meriney SD. Gundersen CB. Umbach JA. (1999) Antibodies against cysteine string proteins inhibit evoked neurotransmitter release at Xenopus neuromuscular junctions. Journal of Neurophysiology 82: 50-59.
Yazejian B. DiGregorio D. Vergara JL. Poage RE. Meriney SD. Grinnell AD. (1997) Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses. Journal of Neuroscience 17: 2990-3001.
White MG. Crumling MA. Meriney SD. (1997) Developmental changes in calcium current pharmacology and somatostatin inhibition of calcium current in chick parasympathetic neurons. Journal of Neuroscience 17: 6302-6313.
Meriney SD. Ezatti E. Wolowski B. Grinnell AD. (1996) Low calcium-induced disruption of active zone structure and function at the frog neuromuscular junction. Synapse 24: 1-11.
Meriney SD. Hulsizer SC. Lennon VA. Grinnell AD. (1996) Lambert-Eaton myasthenic syndrome IgG removes multiple types of calcium channels from a human small cell lung cancer cell line. Annals of Neurology 40: 739-749.
Pilar, G., D.B. Gray & S.D. Meriney (1996) Membrane delimited and intracellular soluble pathways in the somatostatin modulation of ACh release. Life Science 58: 1979-1996.
Meriney SD. Gray DB. Pilar GR. (1994) Somatostatin-induced inhibition of neuronal Ca2+ current modulated by cGMP-dependent protein kinase. Nature 369: 336-339.
Meriney SD. Grinnell AD. (1991) Endogenous adenosine modulates stimulation-induced depression at the frog neuromuscular junction. Journal of Physiology (London) 443: 441-455.
Hulsizer SC. Meriney SD. Grinnell AD. (1991) Calcium currents in presynaptic varicosities of embryonic motoneurons. Annals of the New York Academy of Science 635: 424-428.
Meriney SD. Ford MJ. Oliva D. Pilar G. (1991) Endogenous opioids modulate neuronal survival in the developing avian ciliary ganglion. Journal of Neuroscience 11: 3705-3717.
Meriney SD. Hulsizer SC. Grinnell AD. (1991) Calcium currents in varicosities of motoneuron neurites ending on muscle cells in vitro. Biomedical Research 12: suppl. 2, 53-55.
Meriney SD. Young SH. Grinnell AD. (1989) Constraints on the interpretation of nonquantal acetylcholine release from the frog neuromuscular junction. Proceedings of the National Academy of Science, U.S.A. 86: 2098-2102.
Grinnell AD. Gundersen CB. Meriney SD. Young SH. (1989) Direct measurement of ACh release from exposed frog nerve terminals: constraints on interpretation of non-quantal release. Journal of Physiology (London) 419: 225-251.
Pilar, G., H.J.L. Freyer, S.D. Meriney and M.J. Ford (1988) The regulation of neuronal number during embryonic chick development. Puerto Rico Health Sciences Journal 7: 149-155.
Pilar, G., S.D. Meriney and D.B. Gray (1988) Trophic effects of muscle on nerve cell survival and development. In:Nerve-Muscle Cell Trophic Communication. ed. H. Fernandez and J, Donoso, CRC Press, Chapter 9, pp 173-198.
Pilar G. Nunez R. McLennon I. Meriney SD. (1987) Muscarinic and nicotinic synaptic activation of the developing chicken iris. Journal of Neuroscience 7: 3813-3826.
Meriney SD. Pilar G. (1987) Cholinergic innervation of the smooth muscle cells in the choroid coat of the chick eye and its development. Journal of Neuroscience 7: 3827-3839.
Meriney SD. Pilar G. Ogawa M. Nunez R. (1987) Differential neuronal survival in the avian ciliary ganglion after chronic acetylcholine receptor blockade. Journal of Neuroscience 7: 3840-3849.
Meriney SD, Gray DB. Pilar G. (1985) Morphine-induced delay of normal cell death in the avian ciliary ganglion. Science 228: 1451-1453.